Review Article
Depression in Temporal Lobe Epilepsy: A Review of Prevalence, Clinical Features, and Management Considerations
Table 1
Positive and negative effects of AED’s [
36].
| | Antiepileptic drug | Negative psychotropic symptoms | Positive psychotropic symptoms |
| | Barbiturates | Depression, hyperactivity | Anxiolytic, hypnotic | Carbamazepine/
oxcarbazepine | Irritability | Mood stabilizer, antimanic | | Ethosuximide | Behavioral abnormalities, psychosis | None identified | | Felbamate | Depression, anxiety, irritability | None identified | | Gabapentin | Behavioral problems in children | None identified | | Lamotrigine | Insomnia, agitation | Mood stabilizer, antidepressant | | Levetiracetam | Irritability, emotional lability | Possible antimanic | | Phenytoin | Encephalopathy | Possible antimanic | | Pregabalin | Unknown | Anxiolytic | | Tigabine | Depression (nonconvulsive status epilepticus) | Possible anxiolytic | | Topiramate | Depression, psychomotor slowing, psychosis | Mood stabilizer | | Valproate | Encephalopathy | Mood stabilizer | | Vigabatrin | Depression, aggression, psychosis | None identified | | Zonisamide | Agitation, depression, psychosis | Possible antimanic |
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