Review Article
Depression in Temporal Lobe Epilepsy: A Review of Prevalence, Clinical Features, and Management Considerations
Table 2
Seizure prevalence in psychiatric samples during treatment with antidepressant drugs [
36].
| Antidepressant | Dosage (mg) | Seizure prevalence (%) |
| Tricyclic Antidepressants (TCA’s) | | | Amitriptyline | <200 mg | 0.1 | >200 mg | 0.6 | Imipramine | 50–600 mg | <0.1–0.9 | Clomipramine | >200 mg | 0.5 | Tetracyclic Antidepressants | | | Maprotiline | 150–200 mg | 0.4 | Mirtazepine | 30 mg | <0.1 | Selective Serotonin Reuptake Inhibitors (SSRI’s) | | | Fluoxetine | 20–60 mg | 0.2 | Fluvoxamine | <100 mg | 0.2 | Sertraline | 50–100 mg | <0.1 | Paroxetine | 20–60 mg | 0.1 | Norepinephrine Dopamine Reuptake Inhibitor (NDRI’s) | | | | 300 mg SR | 0.1 | Bupropion | 300–450 mg IR | 0.4 | | >450 mg IR | >0.6 |
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