Research Article

Regioselective 5-exo-Trig Heterocyclization of 2-Allyl-1-naphthols under the Influence of N-Iodosuccinimide or Molecular Iodine in Aqueous Micelle

Table 2

Summarized results of the cyclization strategy in two methods

EntrySubstrateProductYield (%)
(Condition A)a
Yield (%)
(Condition B)a

13a4a7688
23b4b7084
33c4c7382
43d4d7183
53e4e7480

Condition A: substrates 3(a–e) (0.5 mmol), NIS (0.5 mmol), MeCN, 0°C-r.t, 2 h; Condition B: substrates 3(a–e) (0.5 mmol), I2 (1.4 equiv.), CTAB (0.30 mmol), H2O (10 mL), r.t, 8 h.
aIsolated yields are reported. (All reactions were performed under the optimized reaction conditions).