Clinical Study
DNase1: No Association with Crohn's Disease in a New Zealand Population
Table 2
Relationships between SNPs and subphenotypes.
| | | rs1053874 (tested allele: G) | rs8176938 (tested allele: C) | | | OR (95% CI) | P | OR (95% CI) | P |
| | Age at diagnosis | <17 | 0.86 (0.54–1.36) | 0.509 | 1.45 (0.45–4.60) | 0.533 | | 17 to 40 | 1.02 (0.81–1.28) | 0.900 | 1.36 (0.80–2.33) | 0.259 | | 40< | 1.08 (0.72–1.62) | 0.707 | 0.86 (0.39–1.89) | 0.712 |
| | CD behaviour | inflammatory | 1.12 (0.88–1.44) | 0.361 | 1.27 (0.72–2.22) | 0.411 | | stricturing | 0.78 (0.58–1.06) | 0.113 | 1.01 (0.53–1.95) | 0.969 | | penetrating | 1.22 (0.74–2.00) | 0.433 | 2.20 (0.53–9.10) | 0.275 |
| | CD location | Ileal | 0.96 (0.72–1.29) | 0.802 | 0.86 (0.49–1.52) | 0.605 | | Colonic | 1.11 (0.82–1.51) | 0.500 | 1.62 (0.74–3.54) | 0.229 | | Ileocolonic | 0.95 (0.69–1.30) | 0.726 | 1.75 (0.75–4.10) | 0.195 |
| | Other IBD family | Y | 0.89 (0.54–1.48) | 0.651 | 1.20 (0.37–3.89) | 0.759 | | Bowel resection | Y | 0.91 (0.68–1.21) | 0.517 | 1.43 (0.70–2.91) | 0.322 | | EIM | Y | 0.89 (0.61–1.32) | 0.568 | 0.90 (0.41–1.98) | 0.799 | | Perianal disease | Y | 1.33 (0.84–2.10) | 0.226 | — | | | Severity | Y | 1.00 (0.69–1.47) | 0.982 | 1.19 (0.51–2.78) | 0.695 | | Smoking | Y | 1.08 (0.74–1.58) | 0.677 | 0.95 (0.34–2.61) | 0.916 |
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