Research Article
A Validated RP-HPLC Method for the Estimation of Pizotifen in Pharmaceutical Dosage Form
| | Condition | Mean area | % assay | % difference |
| | Unaltered | 144805.5 | 100.0 | 0.0 | | Flow rate at 0.8 mL/min | 144720.3 | 99.94 | 0.06 | | Flow rate at 1.2 mL/min | 143951.2 | 99.41 | 0.59 | | Mobile phase: | | | | | Acetonitrile : Methanol | | | | |
92%08% | 144902.5 | 100.06 | 0.06 | |
88%12% | 144763.4 | 99.97 | 0.03 | | pH of mobile phase at 6.0 | 144275.2 | 99.63 | 0.37 | | pH of mobile phase at 5.6 | 144358.7 | 99.69 | 0.31 |
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