Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2
Figure 3
Comparison of the protein isoforms coded by the x-III ORF of HTLV-1 and HTLV-2. Indicated is the exon composition of the mRNAs (left) and the domain structure of the corresponding proteins (right) coded by the x-III ORFs of HTLV-1 and HTLV-2. HTLV-1 produces a single truncated x-III ORF: p21rex; HTLV-2 produces a family of truncated x-III isoforms ranging from 22 to 17 kDa. RBD/NLS: rna binding domain/nuclear localization signal; MD: multimerization domain; AD/NES: activation domain/nuclear export signal; PS: phosphorylation site.
