Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr class="thead"><td align="left"></td><td align="center">ORF x-I</td><td align="center">ORF x-II</td><td align="center">ORF x-III</td><td align="center">ORF x-IV</td><td align="center">ORF x-V</td><td align="center">Minus strand</td></tr><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr><td align="left">HTLV-1</td><td align="center">p12, p8</td><td align="center">p30, p13 </td><td align="center">Rex, p21Rex</td><td align="center">Tax</td><td align="center">—</td><td align="center">HBZ</td></tr><tr><td align="left">HTLV-2</td><td align="center">p10</td><td align="center">p28</td><td align="center">Rex, tRex</td><td align="center">Tax</td><td align="center">p11</td><td align="center">APH-2</td></tr><tr class="table-tr"><td colspan="7"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Regulatory and accessory proteins coded by HTLV-1 and HTLV-2. The proteins with recognized functional analogies in the two viruses are indicated in bold. p8 and p13 proteins (indicated in bold italic) are unique to HTLV-1; p11 (indicated in italic) is unique to HTLV-2. 

Leukemia Research and Treatment

tab1

Table 1

Table 1: Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2 