Biomarker Discovery of Pancreatic and Gastrointestinal Cancer by 2DICAL: 2-Dimensional Image-Converted Analysis of Liquid Chromatography and Mass Spectrometry
Figure 2
Discovery and validation of CXC chemokine ligand 7 as a pancreatic cancer biomarker (partially changed from [10]). (a) 2DICAL images of peptide peak (m/z, 863; RT, 50.2 min) with coordinates RT versus patients (upper) and intensity versus patients (bottom). Red indicates samples from pancreatic cancer patients, and blue indicates samples from healthy controls. (b) Western blot of CXC chemokine ligand 7 (upper panel) and the loading control Complement C3b-α. (c) Large-scale RPPA validation of the plasma level of CXC chemokine ligand 7 using hundreds of clinical samples.
