Chemotherapy Research and Practice

Research Article

Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles

Table 2

In vitro cytotoxicity of free oxaliplatin and DACHPt/cl-micelles against A2780 ovarian cancer cell line.
TreatmentIC50 (DACHPt equivalents in μg/mL)a
OxaliplatinDACHPt/cl-micelles
24 h0.982 ± 0.050.812 ± 0.11
48 h0.726 ± 0.070.433 ± 0.09b
72 h0.517 ± 0.150.114 ± 0.07b
aValues are mean ± standard deviation ( ).
bSignificantly different from oxaliplatin treatment ( ).