Representative histopathology slides and corresponding pathology reports on a rat liver during the chronic phase (magnification ×40). (a) Section of a rat liver 24 hours after dosing with S and NVP in a group treated daily with NVP for 7 days (S + NVP). Pathology report: “mild centrilobular hepatocellular degeneration and cell swelling with a cloudy appearance of the cytoplasm of hepatocytes in the central part of the liver lobules. On the periphery, moderate hepatocellular apoptosis. The Kuppfer cells are prominent with mild lymphocytic infiltration of the portal tracts and isolated perivascular lymphoplasmacytic cuffing …”. (b) Section of a rat liver 24 hours after dosing with S and NVP in a group treated daily with NVP for 14 days (S + NVP). Pathology report: “Normal liver”. (c) Section of a rat liver 24 hours after dosing with S and NVP in a group treated daily with NVP for 21 days (S + NVP). Pathology report: “Normal liver”. (d) Section of a rat liver 24 hours after dosing with LPS and NVP in a group treated daily with NVP for 7 days (LPS + NVP). Pathology report: “moderate apoptosis, and mild lymphocytic infiltration with perivascular distribution in the portal areas.” (e) Section of a rat liver 24 hours after dosing with LPS and NVP in a group treated daily with NVP for 14 days (LPS + NVP). Pathology report: “Normal liver”. (f) Section of a rat liver 24 hours after dosing with LPS and NVP in a group treated daily with NVP for 21 days (LPS + NVP). Pathology report: “Normal liver.”