T-817MA, but Not Haloperidol and Risperidone, Restores Parvalbumin-Positive γ-Aminobutyric Acid Neurons in the Prefrontal Cortex and Hippocampus of Rats Transiently Exposed to MK-801 at the Neonatal Period
Figure 4
(a–c) Effect of 14-day (PD 49–62) treatment with T-817MA, HPD, or RPD on the density of PV-positive GABAergic interneuron cells (cells/mm2) in the hippocampal subfields, that is, DG (a), CA1 (b), and CA2/3 (c), in rats that did or did not receive neonatal treatment with MK-801. DW group (), HPD group (), RPD group (), and T-817MA group () treated neonatally with saline are shown in the left side. DW group (), HPD group (), RPD group (), and T-817MA group () treated neonatally with MK-801 are shown in the right side. Data of saline group (open bars), HPD group (dark bars), RPD group (shaded bars) and T-817MA group (closed bars) are shown. Values are expressed as means SEM. #; as compared with saline-DW group. *; as compared with MK801-DW group. (d)–(f) Photomicrographs of PV-positive neurons in subregions of hippocampus from rats on PD 63; DG (d), CA1 (e), and CA2/3 (f).