Liquid Chromatographic Method for the Quantification of Antipsychotic Agent Iloperidone in Pharmaceutical Formulation

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Condition</td><td align="center">Time (h)</td><td align="center">% Recovery ILO</td><td align="center">Retention time of degradation products</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">Base 1 N NaOH</td><td align="center">1 week</td><td align="center">100.4</td><td align="center">—</td></tr><tr><td align="left">Acid 1 N HCl</td><td align="center">1 week</td><td align="center">99.1</td><td align="center">—</td></tr><tr><td align="left">3% hydrogen peroxide</td><td align="center">2</td><td align="center">81.7</td><td align="center">13.53, 14.32</td></tr><tr><td align="left">Dry heat<sup>b</sup></td><td align="center">1 week</td><td align="center">99.7</td><td align="center">—</td></tr><tr><td align="left">Sunlight</td><td align="center">1 week</td><td align="center">99.3</td><td align="center">—</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><sup>
									b</sup>Samples were heated at 80°C for a specified period of time.<br/></td></tr></table>

Data derived from forced degradation study for  the proposed HPLC method.

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Table 4

Table 4: Liquid Chromatographic Method for the Quantification of Antipsychotic Agent Iloperidone in Pharmaceutical Formulation 