Review Article
Cancer Treatment Using Peptides: Current Therapies and Future Prospects
Table 1
LHRH agonists and new generation antagonists available in the market.
| Peptide | Sequence comparison | Indications |
| Agonists | | | Buserelin | Pyr-His-Trp-Ser-Tyr-D-Ser(OtBu)-Leu-Arg-Pro-NHEt | Prostate cancer | Gonadorelin | Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 | Cystic ovarian disease, agent for evaluating hypothalamic-pituitary gonadotropic function | Goserelin | Pyr-His-Trp-Ser-Tyr-D-Ser(OtBu)-Leu-Arg-Pro-AzGly-NH2 | Prostate cancer; breast cancer | Histrelin | Pyr-His-Trp-Ser-Tyr-D-His(N-benzyl)-Leu-Arg-Pro-NHEt | Prostate cancer; breast cancer | Leuprolide | Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt | Prostate cancer; breast cancer | Nafarelin | Pyr-His-Trp-Ser-Tyr-2Nal-Leu-Arg-Pro-Gly-NH2 | Treat symptoms of endometriosis, central precocious puberty | Triptorelin | Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 | Prostate cancer; breast cancer |
| Antagonists | | | Abarelix | Ac-D-2Nal-D-4-chloroPhe-D-3-(3′-pyridyl) Ala-Ser-(N-Me)Tyr-D-Asn-Leu-isopropylLys-Pro-DAla-NH2 | Prostate cancer | Cetrorelix | Ac-D-2Nal-D-4-chloroPhe-D-3-(3′-pyridyl) Ala-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2 | Prostate cancer; breast cancer | Degarelix | Ac-D-2Nal-D-4-chloroPhe-D-3-(3′-pyridyl) Ala-Ser-4-aminoPhe(L-hydroorotyl)-D-4-aminoPhe(carbamoyl)-Leu-isopropylLys-Pro-D-Ala-NH2 | Prostate cancer | Ganirelix | Ac-D-2Nal-D-4-chloroPhe-D-3-(3′-pyridyl) Ala-Ser-Tyr-D-(N9, N10-diethyl)-homoArg-Leu-(N9, N10-diethyl)-homoArg-Pro-D-Ala-NH2 | Fertility treatment |
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