Proposed mechanism of receptor trafficking. The scheme illustrates the fundamental events associated with trafficking of this receptor that is known to require HSPA5 [13, 14] and dynein [20]. We include in our working model that GAPDH may be playing a role in some aspects of this process due to its known affinity to dynein, the receptor α-subunit, and biomembranes. This mechanism is consistent with the observation that isoflurane promotes trafficking of another neuronal membrane transport protein [26]. The current study supports this model, including isoflurane-induced enhancement of GAPDH-mediated processes (i.e., membrane fusion and cytoplasmic loop binding).