Research Article

Biodegradable In Situ Gel-Forming Controlled Drug Delivery System Based on Thermosensitive Poly( -caprolactone)-Poly(ethylene glycol)-Poly( -caprolactone) Hydrogel

Table 2

Comparison of different synthesis methods based on the time and the yield of the reaction.

Kind of the copolymer Synthesis methodTime of the reaction Yield of the reactions (%)

Copolymer 1Two-necked flask 6 hours56
Copolymer 2Two-necked flask 6 hours68
Copolymer 1Stainless steel reactor 6 hours73
Copolymer 2Stainless steel reactor 6 hours79
Copolymer 1Microwave irradiation25 min93
Copolymer 1Microwave irradiation15 min95
Copolymer 1Microwave irradiation20 min96