International Scholarly Research Notices / 2013 / Article / Tab 3 / Review Article
Models for the Study of Whole-Body Glucose Kinetics: A Mathematical Synthesis Table 3 Example literature values from insulin-dependent minimal model for describing glucose kinetics.
Reference Population (species) ;
per group; body weight (kg) Experimental groups/conditions Test Isotope GE (min−1 ) IS (
U−1 min−1 mL × 10−4 )* C T C T [19 ] Canine (Mongrel) ; 5 (C); 8 (T); ~25 Low (C) versus high (T) dose IVGTT — — — 13.9 ± 5.37 7.00 ± 0.59 [20 ] Canine (Beagle) ; 6; 11 ± 2 Cold (no isotope) (C) versus labelled (T) IVGTT 2-3 H 0.042 ± 0.009 0.009 ± 0.001 4.52 ± 1.39 6.41 ± 0.91 [24 ] Canine (Mixed) ; 8; 27.2 ± 1.1 Healthy (C) versus Acepromazine (T) IVGTT — 0.04 ± 0.01 0.03 ± 0.00 6.6 ± 1.0 7.7 ± 2.3 [25 ] Canine (Mixed) ; 6; 22 ± 4.4 (C); 45 ± 18.4 (T) Healthy (C) versus obese (T) IVGTT — — — 3.0 ± 0.8 6.5 ± 1.5 [26 ] Canine (Mongrel) ; 9; 35.9 ± 1.4 (C); 42.4 ± 2.1 (T) Chow diet (C) versus high fat diet (T) tmIVGTT — 0.031 ± 0.40 0.020 ± 0.26 13.6 ± 1.74 5.87 ± 1.21 [27 ] Canine (Mongrel) ; 6; 28.2 ± 1.7 Chow diet (C) versus high fat diet (T) imIVGTT — 0.041 ± 0.004 0.051 ± 0.006 3.98 ± 0.54 1.40 ± 0.55 [28 ] Canine (Mixed) ; 8, ~13 Healthy (C) versus hypothyroid (T) imIVGTT — 0.043 ± 0.009 0.043 ± 0.011 23.6 ± 5.3 4.9 ± 1.2 [23 ] Feline (Domestic Shorthair) ; 10; 3.74 ± 0.36 (C); 6.6 ± 0.79 (T) Healthy (C) versus obese (T) EHC 3-3 H 0.016 0.013 2.58 ×
IVGTT 3-3 H — — 6.27 ×
C, control group; T, treatment group, GE, glucose effectiveness; IS, insulin sensitivity; IVGTT, intravenous glucose tolerance test; tmIVGTT, tolbutamide modified intravenous glucose tolerance test; imIVGTT, insulin modified glucose tolerance test; EHC, euglycemic hyperinsulinemic clamp;
refers to per unit of concentration;
units of min−1 pmol−1 L; data are presented as mean ± SE.