International Scholarly Research Notices

Review Article

Models for the Study of Whole-Body Glucose Kinetics: A Mathematical Synthesis

Table 3

Example literature values from insulin-dependent minimal model for describing glucose kinetics.


Reference	Population (species); per group; body weight (kg)	Experimental groups/conditions	Test	Isotope	GE (min⁻¹)		IS (U⁻¹ min⁻¹ mL × 10⁻⁴)*
Reference	Population (species); per group; body weight (kg)	Experimental groups/conditions	Test	Isotope	C	T	C	T

[19]	Canine (Mongrel); 5 (C); 8 (T); ~25	Low (C) versus high (T) dose	IVGTT	—	—	—	13.9 ± 5.37	7.00 ± 0.59
[20]	Canine (Beagle); 6; 11 ± 2	Cold (no isotope) (C) versus labelled (T)	IVGTT	2-³H	0.042 ± 0.009	0.009 ± 0.001	4.52 ± 1.39	6.41 ± 0.91
[24]	Canine (Mixed); 8; 27.2 ± 1.1	Healthy (C) versus Acepromazine (T)	IVGTT	—	0.04 ± 0.01	0.03 ± 0.00	6.6 ± 1.0	7.7 ± 2.3
[25]	Canine (Mixed); 6; 22 ± 4.4 (C); 45 ± 18.4 (T)	Healthy (C) versus obese (T)	IVGTT	—	—	—	3.0 ± 0.8	6.5 ± 1.5
[26]	Canine (Mongrel); 9; 35.9 ± 1.4 (C); 42.4 ± 2.1 (T)	Chow diet (C) versus high fat diet (T)	tmIVGTT	—	0.031 ± 0.40	0.020 ± 0.26	13.6 ± 1.74	5.87 ± 1.21
[27]	Canine (Mongrel); 6; 28.2 ± 1.7	Chow diet (C) versus high fat diet (T)	imIVGTT	—	0.041 ± 0.004	0.051 ± 0.006	3.98 ± 0.54	1.40 ± 0.55
[28]	Canine (Mixed); 8, ~13	Healthy (C) versus hypothyroid (T)	imIVGTT	—	0.043 ± 0.009	0.043 ± 0.011	23.6 ± 5.3	4.9 ± 1.2
[23]	Feline (Domestic Shorthair); 10; 3.74 ± 0.36 (C); 6.6 ± 0.79 (T)	Healthy (C) versus obese (T)	EHC	3-³H	0.016	0.013	2.58 ×
			IVGTT	3-³H	—	—	6.27 ×

C, control group; T, treatment group, GE, glucose effectiveness; IS, insulin sensitivity; IVGTT, intravenous glucose tolerance test; tmIVGTT, tolbutamide modified intravenous glucose tolerance test; imIVGTT, insulin modified glucose tolerance test; EHC, euglycemic hyperinsulinemic clamp; refers to per unit of concentration; units of min⁻¹ pmol⁻¹ L; data are presented as mean ± SE.