International Scholarly Research Notices

Review Article

Models for the Study of Whole-Body Glucose Kinetics: A Mathematical Synthesis

Table 4

Example literature values from insulin-independent two-pool model for describing glucose kinetics.


Reference	Population (species); per group; body weight (kg)	Experimental groups/conditions	Isotope	(mL kg⁻¹)	(mg kg⁻¹min⁻¹)	Fractional rate constant (min⁻¹)				GE (min⁻¹)


[31]	Canine (Mongrel); 4; ~13	IVGTT	6-³H	122	2.38	0.141	0.054	0.064	0	—
		IVGTT	6-³H	122	1.85	0.061	0.049	0.072	0.061	—
		IVGTT	1-¹⁴C	117	2.23	0.170	0.048	0.056	0	—
		IVGTT	1-¹⁴C	117	1.77	0.072	0.041	0.066	0.072	—
[32]	Canine (Mongrel); 8; 25.8 ± 1.0	IVGTT	3-³H	132	—	0.021 ± 0.001	0.111 ± 0.023	0.123 ± 0.029	0	0.030 ± 0.002
[30]	Feline (Domestic Shorthair); 10; 3.74 ± 0.36 (C); 6.6 ± 0.79 (T)	Healthy (C) versus obese (T) during EHC	3-³H	253.4^†	—	0.000	101.6 (C); 68.2 (T)^‡	101.6 (C); 68.2 (T)^‡	0.0378	—

C, control group; T, treatment group; GE, glucose effectiveness (min⁻¹); IVGTT, intravenous glucose tolerance test; EHC, euglycemic hyperinsulinemic clamp; ^†units of mL; ^‡units of mL min⁻¹; data are presented as mean ± SE.