Review Article
Models for the Study of Whole-Body Glucose Kinetics: A Mathematical Synthesis
Table 5
Example literature values of insulin-dependent two-pool model for describing glucose kinetics.
| | Reference | Population
(species); per group; body weight (kg) | Experimental conditions | Test | Isotope |
(mL kg−1) |
(mg kg−1 min−1) |
(μU/mL) min−1 | Fractional rate constant
(min−1)
| GE
(min−1) | IS
(μU−1 min−1 mL × 10−4)* | HGO
(mg kg−1min−1) | | | | | | | | | | | | | | | | |
| | [33] | Human; 6; BW not reported | N/A | IGVTT | 2-3H & 6,6-2H2 | 124 | 1 | — | 0.067 | 0.052 | 0.040 | 0.031 | 0.025 | — | — | 1.63 | | [34] | Human; 10;
62 ± 3 | IVGTT | U-13C | 155 ± 10 | 139 ± 3.7 | 1 | — | 0.01 | 0.070 ± 0.008 | 0.080 ± 0.014 | 0.004 ± 0.000 | 0.115 ± 0.023 | — | — | — | | [32] | Canine (Mongrel); 8;
35.6 ± 1.3 | No insulin | IVGTT | 3-3H | 157 ± 14 | 0 | 2.65 ± 0.78 | 0.010 ± 0.002 | 0.106 ± 0.025 | 0.147 ± 0.041 | 0.007 ± 0.001 | 0.228 ± 0.058 | — | — | 3.21 ± 0.49 | | | | Insulin injected into portal vein | imIVGTT | | 158 ± 6 | 0 | 3.51 ± 0.75 | 0.011 ± 0.001 | 0.111 ± 0.012 | 0.182 ± 0.023 | 0.018 ± 0.002 | 0.262 ± 0.049 | 0.031 ± 0.412 | 3.69 ± 0.56 | — | | | | Insulin injected into femoral vein | imIVGTT | | 155 ± 5 | 0 | 2.81 ± 0.80 | 0.012 ± 0.003 | 0.114 ± 0.020 | 0.211 ± 0.043 | 0.010 ± 0.002 | 0.195 ± 0.004 | 0.030 ± 0.412 | 3.35 ± 0.60 | — | | [35] | Human; 10;
62 ± 3 | N/A | imIVGTT | 6,6-3H | 191 ± 92 | 1 | — | 0.012 | 0.068 ± 0.012 | 0.106 ± 0.024 | 0.006 ± 0.001 | 0.131 ± 0.030 | — | 3.77 ± 0.52 | 5.22 ± 0.55 |
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GE, glucose effectiveness; IS, insulin sensitivity; HGO, hepatic glucose output; IVGTT, intravenous glucose tolerance test; imIVGTT, insulin modified glucose tolerance test; data are presented as mean ± SE.
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