Review Article

Serum Biomarkers Identification by Mass Spectrometry in High-Mortality Tumors

Table 2

Liver cancer serum biomarkers identified after MS-based studies.

Putative liver cancer biomarkerExpression in liver ca seraReferences

Complement c3Increased[55]
Histidine rich glycoproteinIncreased[55]
CD14Increased[55]
Hepatocyte growth factorIncreased[55]
C-terminal part of vitronectin V10 fragmentIncreased[56]
Protein complement C3aIncreased[57]
Annexin VI isoformIncreased[58]
Complement component 9Increased[58]
CeruloplasminIncreased[55, 58]
Serum amyloid A4Increased[58]
Serum amyloid A2Increased[58]
Serum amyloid A1 isoform 2Increased[58]
Cystatin CIncreased[59]
Neutrophil-activating peptide 2Increased[60]
Thrombin light chainIncreased[61]
Growth-related oncogene alpha (GRO-alpha)Increased[61]
Alpha-1 acid glycoproteinIncreased[62]
HaptoglobinIncreased[63]
N terminus complement C3fDecreased[64]
FibrinopeptideDecreased[64]
Complement C4 alpha peptidesIncreased[64]
Zyxin peptideIncreased[64]
Coagulation factor XIII peptideIncreased[64]
Biliverdin diglucuronideIncreased[64]
Heat-shock protein 27Increased[65]
MYH2 proteinIncreased[66]
Mitochondrial ATP synthaseIncreased[66]
Sulphated glycoprotein-2Increased[66]
Glial fibrillary acidic proteinIncreased[66]