Review Article
Serum Biomarkers Identification by Mass Spectrometry in High-Mortality Tumors
Table 2
Liver cancer serum biomarkers identified after MS-based studies.
| Putative liver cancer biomarker | Expression in liver ca sera | References |
| Complement c3 | Increased | [55] | Histidine rich glycoprotein | Increased | [55] | CD14 | Increased | [55] | Hepatocyte growth factor | Increased | [55] | C-terminal part of vitronectin V10 fragment | Increased | [56] | Protein complement C3a | Increased | [57] | Annexin VI isoform | Increased | [58] | Complement component 9 | Increased | [58] | Ceruloplasmin | Increased | [55, 58] | Serum amyloid A4 | Increased | [58] | Serum amyloid A2 | Increased | [58] | Serum amyloid A1 isoform 2 | Increased | [58] | Cystatin C | Increased | [59] | Neutrophil-activating peptide 2 | Increased | [60] | Thrombin light chain | Increased | [61] | Growth-related oncogene alpha (GRO-alpha) | Increased | [61] | Alpha-1 acid glycoprotein | Increased | [62] | Haptoglobin | Increased | [63] | N terminus complement C3f | Decreased | [64] | Fibrinopeptide | Decreased | [64] | Complement C4 alpha peptides | Increased | [64] | Zyxin peptide | Increased | [64] | Coagulation factor XIII peptide | Increased | [64] | Biliverdin diglucuronide | Increased | [64] | Heat-shock protein 27 | Increased | [65] | MYH2 protein | Increased | [66] | Mitochondrial ATP synthase | Increased | [66] | Sulphated glycoprotein-2 | Increased | [66] | Glial fibrillary acidic protein | Increased | [66] |
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