Journal of Allergy

Clinical Study

TNF-Alpha Inhibitors for Chronic Urticaria: Experience in 20 Patients

Table 1

Characteristics of 20 patients with severe chronic urticaria treated with TNF-alpha inhibitors.


Patient characteristics			Urticaria characteristics		TNF-alpha inhibitor treatment
No.	Sex	Age	Type	Previous treatment	Type	Duration	Effect	Side effects

1	F	43	CSU/AE	H1, Pred, and Aza	Ada	39 m	+	URI
2	F	48	CSU	H1, Pred, Aza, CyA, and MPM	Ada	30 m	++	None
3	M	64	CSU	H1, Pred, and CyA	Ada	29 m	++	None
4	F	38	CSU/AE	H1, Pred, and Oma	Ada	19 m	++	None
5	F	49	CSU	H1, CyA	Ada	16 m	+	None
6	F	31	CSU	H1, Pred, and Oma	Eta	10 m	++	None
7	F	51	NU	H1, CyA, Dap, and Col	Ada	9 m	−	None
8	M	24	CSU	H1, Pred, and Oma	Eta	8 m	++	None
9	M	58	CAU	H1, Pred, and Aza	Ada	6 m	++	None
10	F	52	CSU/AE	H1, Pred, Aza, and MPM	Ada	6 m	++	URI
11	M	29	CSU	H1, Pred, and CyA	Ada	5 m	++	None
12	F	50	CSU/AE	H1, Pred, and Oma	Eta	5 m	+	URI
13	F	74	CSU	H1, Pred, Aza, and CyA	Ada	4 m	++	None
14	F	31	CSU/AE	H1, Pred, and Oma	Ada	3 m	++	CNS
15	F	32	CAU	H1, Pred	Ada	3 m	++	URI
16	F	48	CSU	H1, Pred, and Oma	Eta	3 m	++	URI
17	F	35	CSU/AE	H1, Pred, and Aza	Ada	3 m	−	None
18	F	43	CSU/AE	H1, Pred, and CyA	Ada	3 m	−	None
19	F	48	CSU	H1, Pred, Aza, and CyA	Ada	2 m	−	None
20	M	47	DPU	H1, Aza, and Oma	Ada	2 m	−	None

CSU: chronic spontaneous urticaria; CAU: chronic autoimmune urticaria (diagnosed by serum-induced basophil histamine release test, RefLab, Copenhagen, Denmark); DPU: delayed pressure urticaria; NU: neutrophilic urticaria; AE: angioedema. H1: antihistamines; Pred: prednisolone; Aza: azathioprine; CyA: cyclosporine A; MPM: mycophenolate mofetil; Oma: omalizumab; Dap: dapsone; Col: colchicine; Ada: adalimumab; Eta: etanercept.
++: complete or almost complete response; +: partial response; −: no/limited response. URI: upper respiratory infection; CNS: CNS toxicity.