New Stability Indicating Method for Quantification of Impurities in Amlodipine and Valsartan Tablets by Validated HPLC

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Component name </td><td align="center">Concentration µg/mL</td><td align="center">% RSD</td><td align="center">Signal to noise <br/>ratio (S/N) </td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">Amlodipine impurity-A</td><td align="center">0.0253</td><td align="center">5.43</td><td align="center">75.672</td></tr><tr><td align="left">Amlodipine </td><td align="center">0.0346</td><td align="center">0.70</td><td align="center">100.156</td></tr><tr><td align="left">Valsartan impurity-B</td><td align="center">1.6145</td><td align="center">0.71</td><td align="center">9168.987</td></tr><tr><td align="left">Valsartan</td><td align="center">1.5900</td><td align="center">0.66</td><td align="center">9977.428</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

S/N ratio of amlodipine, valsartan and composite impurities at LOQ (0.05%) level.

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Table 5

Table 5: New Stability Indicating Method for Quantification of Impurities in Amlodipine and Valsartan Tablets by Validated HPLC 