Free energy (), enthalpy (), and entropy () changes for the stepwise complex formation reactions at and various coordination levels (data from Table 2). The general sequence of the substratum to ligand affinity, enthalpy, and entropy changes (i) in the reactions of () substrata with the same ligands as dependent on the coordination level of the reacting substratum, (ii) in the reactions () in dependence on the alkyl substitution at the same coordination level and (iii) the concurrent changes in the corresponding and are evident. Such parallelism in the and occurs very often in homologous series of reactions [10–13].