Ulcers

Research Article

Chronic Nonhealing Wounds: Could Leg Ulcers Be Hereditary?

Table 2

Putative genetic factors predisposing to VLU development.
 Detected genetic abnormalityPopulationAuthorJournalYear
(1)F5 gene R506Q (Leiden)*GermanPeus et al.J Am Acad Dermatol1996
(2)F2 gene G20210A*RomanianJebeleanu et al.J Cell Mol Med2001
(3)F13A gene V34LItalianGemmati et al.Wound Repair Regen2004
(4)FGFR2 gene 3′ UTR A2451G*HungarianNagy et al.J Invest Dermatol2005
(5)ESRB gene CA repeat D14S1026UKAshworth et al.J Steroid Biochem Mol Biol2005
(6)HFE gene C282YItalianZamboni et al.J Vasc Surg2005
(7)TNFA gene promoter −308*AustralianWallace et al.J Invest Dermatol2006
HungarianNagy et al.J Invest Dermatol2007
(8)FPN1 gene promoter −8GGItalianGemmati et al.J Vasc Surg2009
(9)MMP12 gene promoter −82AAItalianGemmati et al.J Vasc Surg2009
(10)Sex chromosome aberrationsAustrianGattringer et al.Acta Derm Venereol2010
(47,XXY/48,XXXY karyotype)
*The distributions of the genotypes and the allele frequencies of these genetic factors were compared in the present study.