International Scholarly Research Notices

Research Article

Soluble ST2 Does Not Regulate TNF- and IL-6 Production in Dengue Virus-Infected Human Monocytes

Table 1

Tumor necrosis factor alpha and interleukin-6 production by human CD14+ monocytes infected with DENV.
 Percentage of monocytes producing cytokinea
 TNF-αIL-6TNF-α/IL-6
Mock 0.6 (0.6–0.9)0.5 (0.4–0.6)0.2 (0.1–0.3)
DENV-2   
 12 h p.i.9.9 (7.9–12.5)5.6 (3.4–8.5)3.6 (1.8–7.2)
 24 h p.i. 0.6 (0.5–1.8)2.9 (0.8–28)0.8 (0.7–7.0)
Percentages were expressed as the median (range) from three healthy subjects processed independently. Mock infected and DENV-infected monocytes were processed simultaneously to detect CD14+ cells and intracellular cytokine.