Review Article
Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis
Table 1
Dietary models of nonalcoholic fatty liver disease.
| Model | Obesity | Insulin resistance | Steatohepatitis | Hepatic fibrosis | Elevated AST and ALT |
| MCD diet | Weight loss | Hepatic insulin resistance | Yes | Yes | Yes | Choline-deficient, L-amino acid defined (CDAA) diet | Weight loss | No | Yes | Yes | Yes | Atherogenic diet | —* | Hepatic insulin resistance | Yes | Yes | — | High-fat diet | Weight gain | Yes | Yes | Slight | — | Fructose diet | — | Yes | No | No | Yes | Adiponectin null | Weight gain | Yes | Yes | Yes | Yes | Sfrp5 knockout | Weight gain | Yes | Yes | — | — | Bid null | Weight gain | Yes | Yes | — | — | Fas adipocyte-specific knockout | Weight gain | Yes | No | — | — | IL-6 and TNF null | — | — | No | — | — | LIKK | No change | Yes | No | No | No | NEMOL-KO | Weight gain | Yes | Yes | — | — | JNK1−/− | Weight gain | Yes | No (only steatosis) | No | — |
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*Indicates no data.
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