Histology scores where 0 = absent/no response, 1 = minimal/barely detectable, 2 = mild/slightly detectable, 3 = moderate/easily detectable, and 4 = marked/very evident for inflammation, macrophages, giant cells, fibrosis/encapsulation, and granulation/vascularization and where 1 = predominantly green (type III collagen), 2 = mixture of green, yellow, and yellow-orange (mixture of type III and type I collagen), and 3 = predominantly red-orange (type I collagen) for collagen morphology.