Clinical Study
Polymorphisms of MTHFR Associated with Higher Relapse/Death Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies
Table 3
Outcome according to each genotype in all patients.
| Gene | Locus or reference SNP ID | | Patients number according to genotype | Relapsed/died of disease |
| MTHFR | C677T | CC | 32 | 5 | CT/TT | 70 | 8 | | | | | 0.540 | MTHFR | A1298C | AA | 67 | 13 | AC/CC | 35 | 0 | | | | | 0.004 | SLCO1B1 | rs11045879 | TT | 42 | 6 | TC/CC | 60 | 7 | | | | | 0.696 | SLCO1B1 | T521C | TT | 73 | 8 | TC/CC | 29 | 5 | | | | | 0.511 | MTHFR | 677CT/TT and 1298AA | no | 18 | 0 | yes | 53 | 8 | | | | | 0.105 |
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All patients who had relapsed or died of disease had MTHFR c.1298AA genotype.
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