| | Formulation technology | Chemical description | Products |
| | Contramid | Controlled release tablets consisting of cross-linked high-amylose starch with tramadol that forms semipermeable outer gel layer generating zero-order release. Compression coded tablet provides biphasic release (25% rapidly released; 75% released within 24 h) | Contramal UNO®, NOAX® UNO, Dolpar®, Monalgic®, Monotramal®, Unitrama®, Tradorec® XL, Tramadolor®, Unitrama®, Tidural®, Rysolt®, and Durotram® XR |
| | Smartcoat | Polymer diffusion-based film technology (drug released by osmosis). Semipermeable coating composed of water permeable film-forming polymer but not water soluble | Ultram® ER |
| | Mundipharma | Hydrophobic matrix system using hydrogenated castor oil | Dolzam®, Zitram® XL, Tramagetic®, Travex®, Tiparol® OD, Tradonal® One, Zydol® XL, and Zamadol® 24 h |
| | SMB Pellets | Pharmaceutical microgranules composed of a core containing tramadol and a porous membrane made of insoluble methacrylic polymers | Monocrixo® LP, Tramium®, Tralodie®, T-Long®, and Dolodol® |
| | Cipher technology | Capsules consisting of extended-release film-coated white beads and an immediate release tablet encapsulated (75% released within 7-8 h and 24 h; 25% rapidly released). | Cip Tramadol® ER |
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