Review Article
Tramadol Extended-Release for the Management of Pain due to Osteoarthritis
Table 5
Potential tramadol drug interactions.
(a) |
| CYP2D6 | Substrates | Inhibitors | Inducers |
| Amphetamine | Amiodarone | Corticosteroids/ dexamethasone Delavirdine Protease inhibitors (indinavir, lopinavir/ritonavir, saquinavir) | Amitriptyline | Amitriptyline | Aripiprazole | Bupropion | Atomoxetine | Celecoxib | Beta-blockers (selected) | Chlorpheniramine | Carbamazepine | Chlorpromazine | | Carvedilol | Cinacalcet | | Chlorpheniramine | Chloroquine | | Chlorpromazine | Cimetidine | | Cinacalcet | Citalopram | | Clomipramine | Clomipramine | | Desipramine | Clemastine | | Dextromethorphan | Cocaine | | Doxazosin | Clozapine | | Flecainide | Desipramine | | Fluvoxamine | Diphenhydramine | | Haloperidol | Doxepin | | Hydrocodone | Doxorubicin | | Imipramine | Escitalopram | | Lidocaine | Duloxetine | | Metoclopramide | Fluoxetine | | Metoprolol | Fluphenazine | | Mexiletine | Fluvoxamine | | Nortriptyline | Haloperidol | | Ondansetron | Hydroxyzine | | Oxycodone | Lomustine | | Paroxetine | Methadone | | Perphenazine | Metoclopramide | | Primaquine | Mibefradil | | Promethazine | Nefazodone | | Risperidone | Norfloxacin | | Tamoxifen | Quinidine | | Thioridazine | Paroxetine | | Timolol | Perphenazine | | Tricyclic antidepressants | Propafenone | | Venlafaxine | Quinidine | | Yohimbine | Ranitidine | | | Ritonavir | | | Sertraline | | | Sertindole | | | Terbinafine | | | Thioridazine | | | Ticlopidine | | | Tricyclic antidepressants | | | Venlafaxine | | | Vinblastine | | | Vinorelbine | |
|
|
(b) |
| CYP2B6 | Substrates | Inhibitors | Inducers |
| Bupropion | Orphenadrine | Barbiturates | Cyclophosphamide | Thiotepa | Phenytoin | Efavirenz | Ticlopidine | Primidone | Ifosfamide | | Rifampin | Meperidine | | | Methadone | | |
|
|
(c) |
| CYP3A4 | Inhibitors | Inducers |
| Amiodarone | Barbiturates | Aprepitant | Carbamazepine | Cannabinoids | Corticosteroids/dexamethasone | Chloramphenicol | Efavirenz | Cimetidine | Ethosux | Ciprofloxacin | Gluteth | Clarithromycin | Griseofulvin | Clomipramine | Modafinil | Clotrimazole | Nevirapine | Cyclosporine | Oxcarbazepine | Delavirdine | Phenylbutazone | Diltiazem | Phenytoin | Erythromycin | Primidone | Fluconazole | Rifabutin | Fluoxetine | Rifampin | Fluvoxamine | Sulfinpyrazone | Indinavir | Troglitazone | Itraconazole | | Ketoconazole | | Metronidazole | | Nefazodone | | Norfloxacin | | Norfluoxetine | | Omeprazole | | Paroxetine | | Propoxyphene | | Quinidine | | Ranitidine | | Ritonavir | | Sertraline | | Venlafaxine | | Verapamil | | Zafirlukast | | Zileuton | |
|
|