Review Article
Tramadol Extended-Release for the Management of Pain due to Osteoarthritis
Table 5
Potential tramadol drug interactions.
| (a) |
| | CYP2D6 | | Substrates | Inhibitors | Inducers |
| | Amphetamine | Amiodarone | Corticosteroids/
dexamethasone
Delavirdine
Protease inhibitors (indinavir, lopinavir/ritonavir, saquinavir) | | Amitriptyline | Amitriptyline | | Aripiprazole | Bupropion | | Atomoxetine | Celecoxib | | Beta-blockers (selected) | Chlorpheniramine | | Carbamazepine | Chlorpromazine | | | Carvedilol | Cinacalcet | | | Chlorpheniramine | Chloroquine | | | Chlorpromazine | Cimetidine | | | Cinacalcet | Citalopram | | | Clomipramine | Clomipramine | | | Desipramine | Clemastine | | | Dextromethorphan | Cocaine | | | Doxazosin | Clozapine | | | Flecainide | Desipramine | | | Fluvoxamine | Diphenhydramine | | | Haloperidol | Doxepin | | | Hydrocodone | Doxorubicin | | | Imipramine | Escitalopram | | | Lidocaine | Duloxetine | | | Metoclopramide | Fluoxetine | | | Metoprolol | Fluphenazine | | | Mexiletine | Fluvoxamine | | | Nortriptyline | Haloperidol | | | Ondansetron | Hydroxyzine | | | Oxycodone | Lomustine | | | Paroxetine | Methadone | | | Perphenazine | Metoclopramide | | | Primaquine | Mibefradil | | | Promethazine | Nefazodone | | | Risperidone | Norfloxacin | | | Tamoxifen | Quinidine | | | Thioridazine | Paroxetine | | | Timolol | Perphenazine | | | Tricyclic antidepressants | Propafenone | | | Venlafaxine | Quinidine | | | Yohimbine | Ranitidine | | | | Ritonavir | | | | Sertraline | | | | Sertindole | | | | Terbinafine | | | | Thioridazine | | | | Ticlopidine | | | | Tricyclic antidepressants | | | | Venlafaxine | | | | Vinblastine | | | | Vinorelbine | |
|
|
| (b) |
| | CYP2B6 | | Substrates | Inhibitors | Inducers |
| | Bupropion | Orphenadrine | Barbiturates | | Cyclophosphamide | Thiotepa | Phenytoin | | Efavirenz | Ticlopidine | Primidone | | Ifosfamide | | Rifampin | | Meperidine | | | | Methadone | | |
|
|
| (c) |
| | CYP3A4 | | Inhibitors | Inducers |
| | Amiodarone | Barbiturates | | Aprepitant | Carbamazepine | | Cannabinoids | Corticosteroids/dexamethasone | | Chloramphenicol | Efavirenz | | Cimetidine | Ethosux | | Ciprofloxacin | Gluteth | | Clarithromycin | Griseofulvin | | Clomipramine | Modafinil | | Clotrimazole | Nevirapine | | Cyclosporine | Oxcarbazepine | | Delavirdine | Phenylbutazone | | Diltiazem | Phenytoin | | Erythromycin | Primidone | | Fluconazole | Rifabutin | | Fluoxetine | Rifampin | | Fluvoxamine | Sulfinpyrazone | | Indinavir | Troglitazone | | Itraconazole | | | Ketoconazole | | | Metronidazole | | | Nefazodone | | | Norfloxacin | | | Norfluoxetine | | | Omeprazole | | | Paroxetine | | | Propoxyphene | | | Quinidine | | | Ranitidine | | | Ritonavir | | | Sertraline | | | Venlafaxine | | | Verapamil | | | Zafirlukast | | | Zileuton | |
|
|
