Tacrolimus Dose Modification in Hematopoietic Cell Transplant Recipients Following a Change in Therapy from Fluconazole to Voriconazole
Table 2
Mean changes in ratios following a switch from fluconazole to voriconazole.
Patient
Tacrolimus administration
Fluconazole and tacrolimus
Voriconazole and tacrolimus
Fluconazole Dose/Route
Mean ratio (ng/mL)/(mg/kg)
SEM
Voriconazole Dose/Route
Mean ratio (ng/mL)/(mg/kg)
SEM
1
PO, BID
400 mg PO QD
359.1
63.8
IV load, 400 mg PO BID
670.0
72.3
2
PO, BID
400 mg PO QD
254.8
13.2
IV load, 300 mg PO BID
886.9
180.7
3
IV, CI
400 mg IV QD
474.4
101.1
IV load, 300 mg PO BID
859.6
204.5
4
PO, BID
400 mg IV QD
642.0
77.1
IV load, 300 mg IV BID
878.5
96.2
5
PO, BID
400 mg PO QD
333.2
34.9
IV load, 300 mg IV BID
953.3
316.0
Pooled Mean
—
—
412.7
58.0
—
849.7
173.9
PO: oral administration, IV: intravenous administration. QD: once daily, BID: two times daily, CI: continuous infusion. ratio: concentration/dose ratio. SEM: standard error of the mean.
