Review Article
Microscopic Colitis: Epidemiology, Pathophysiology, Diagnosis and Current Management—An Update 2013
Table 2
Histopathological features of collagenous colitis and lymphocytic colitis.
| Collagenous colitis | Lymphocytic colitis |
| (1) Thickening of a subepithelial collagen layer of more than 10 um | (1) Intraepithelial lymphocytosis (≥20 IEL per 100 surface epithelial cells) | (2) Inflammation in the lamina propria consisting of mainly lymphocytes and plasma cells | (2) Inflammation in the lamina propria consisting of mainly lymphocytes and plasma cells | (3) Epithelial damage, such as flattening and detachment. | (3) Epithelial damage, such as flattening and detachment | (4) Intraepithelial lymphocytosis (IEL) could be present, but is not necessary for the diagnosis of CC | (4) Subepithelial collagen layer not present or less than <10 um |
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