Continuation or Discontinuation of Statin Therapy Did Not Influence Patient Outcomes after the Development of Acute Respiratory Distress Syndrome
Table 1
Patient demographics.
Characteristic
Statin before and after ARDS ()
Statin before but not after ARDS ()
Statin never ()
value
Age (years)
68.0 (52.0–77.0)
68.5 (55.5–76.5)
55.0 (40.8–68.3)
0.004
Male gender
8 (47.1)
13 (65.0)
66 (44.0)
0.21
APACHE II
24.0 (19.0–28.0)
27.0 (22.3–30.8)
26.0 (20.0–30.0)
0.38
SOFA
7.0 (6.5–9.5)
9.0 (7.0–10.0)
8.0 (7.0–11.0)
0.59
Ethnicity
0.97
White, non-Hispanic
13 (76.5)
15 (75.0)
111 (74.0)
Black, non-Hispanic
4 (23.5)
5 (25.0)
37 (24.7)
Other
0
0
2 (1.3)
Medical comorbidities
CAD
7 (41.2)
10 (50.0)
26 (17.3)
0.001
Prior MI
1 (5.9)
6 (30.0)
13 (8.7)
0.012
Hyperlipidemia
12 (70.6)
12 (60.0)
11 (7.3)
<0.001
Hypertension
11 (64.7)
13 (65.0)
68 (45.3)
0.10
Heart failure (Class I–III)
6 (35.3)
7 (35.0)
29 (19.3)
0.12
PVD
3 (17.6)
4 (20.0)
10 (6.7)
0.065
Stroke
5 (29.4)
1 (5.0)
11 (7.3)
0.009
Diabetes mellitus
12 (70.6)
10 (50.0)
42 (28.0)
0.001
Dementia
0
2 (10.0)
5 (3.3)
0.23
Chronic pulmonary disease
1 (5.9)
5 (25.0)
30 (20.0)
0.30
Arthritis
2 (11.8)
1 (5.0)
7 (4.7)
0.47
Chronic dialysis
0
1 (5.0)
7 (4.7)
0.66
Leukemia
0
1 (5.0)
4 (2.7)
0.64
Lymphoma
1 (5.9)
0
6 (4.0)
0.60
Immune suppression
4 (23.5)
4 (20.0)
38 (25.3)
0.87
Cirrhosis
0
0
6 (4.0)
0.47
Ethanol abuse
0
1 (5.0)
12 (8.0)
0.44
Transplant
1 (5.9)
1 (5.0)
11 (7.3)
0.91
Acute renal failure
4 (23.5)
2 (10.0)
30 (20.0)
0.51
Admission type
Medical
16 (94.1)
20 (100.0)
143 (95.3)
0.59
Elective surgical
1 (5.9)
0
5 (3.3)
0.59
Emergent surgical
0
0
2 (1.3)
0.78
Category of lung injury
Pneumonia
10 (58.8)
10 (50.0)
69 (46.0)
0.59
Sepsis
4 (23.5)
7 (35.0)
47 (31.3)
0.74
Aspiration
2 (11.8)
2 (10.0)
15 (10.0)
0.97
Multiple transfusion
0
0
0
Trauma
0
0
0
Corticosteroid administration
11 (64.7)
12 (60.0)
80 (53.3)
0.60
Fluid balance during ARDS (liters)
10.9 (1.5–25.6)
6.0 (1.6–10.4)
4.9 (0–13.4)
0.32
Values on ARDS diagnosis date
PaO2 : FiO2
130 (71–233)
93 (71–176)
122 (89–188)
0.35
Tidal volume (mL/kg PBW)
8 (7–8.5)
7.7 (7.3–8.8)
7.3 (6.7–8.6)
0.5
Vasopressor administration
9 (52.9)
7 (35.0)
60 (40.0)
0.51
NMBA
6 (35.3)
3 (15.0)
19 (12.7)
0.05
Fluid balance (liters)
1.1 (0.4–3.1)
2.3 (0.5–4.0)
1.5 (0.5–3.2)
0.71
Enrolled in the ARDS Network Fluid and Catheter Treatment Trial
8 (47.1)
7 (35.0)
44 (29.3)
0.31
Data presented as (%) or median (IQR). ARDS: acute respiratory distress syndrome; APACHE: Acute Physiology and Chronic Health Evaluation II; SOFA: Sequential Organ Failure Assessment; CAD: coronary artery disease; MI: myocardial infarction; PVD: peripheral vascular disease; PBW: predicted body weight.
