Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D<sub>3</sub> Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra

<table>Effect of 0.5 <i>μ</i>g kg<sup>−1</sup> EX-4 alone or in the presence of EX-9-39 or NAF on striatal tissue DA. Both antagonists were coadministered with EX-4 twice daily for seven days, one week after toxin injection. Results were analyzed using one-way ANOVA (<svg height="11.375" id="M9" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.637497 11.375" width="66.637497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>; <svg height="11.375" id="M10" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.875 11.375" width="66.875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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</svg>) and a post hoc Bonferroni test to compare differences between groups. Results were analyzed using one-way ANOVA (<svg height="11.375" id="M11" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.637497 11.375" width="66.637497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>; <svg height="11.375" id="M12" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 75.025002 11.375" width="75.025002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) and a post hoc Bonferroni test to compare differences between groups. *<svg height="11.375" id="M13" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.875 11.375" width="66.875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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</svg> compared to 6-OHDA, 6-OHDA + EX-4 + EX-(3-39), and 6-OHDA + EX-4 + NAF groups; **<svg height="11.375" id="M14" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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</svg> compared to shams, 6-OHDA, 6-OHDA + EX-4, EX-4, EX-(9-39), and NAF.</table>

Journal of Neurodegenerative Diseases

fig2

Figure 2

Figure 2: Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D<sub>3</sub> Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra 

Figure 2 | Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D3 Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra 