International Scholarly Research Notices

Review Article

Should Finasteride Be Routinely Given Preoperatively for TURP?

Table 1

Table showing included studies results.

(a)


	No (Fin versus Pl)	Age	Resection weight grams	PSA	Catheters	Prostate Ca	Complications

Özdal et al. 2005 [10]	20 versus 20	Mean SD: versus ; ND	Mean SD: versus ; ND	Mean SD: versus ; ND			Transient (<3 months) impotence: 1 versus 0 Transient decreased libido: 2 versus 0 2 patients in the placebo group required blood transfusion	Blood loos mean SD: versus ; Bleeding per resected gram of prostate tissue: versus ; Hb decrease: versus ;

Donohue et al. 2005 [1]	31 versus 33	Mean: 70 versus 71; ND	Mean SD: versus ; ND	Mean SD: versus ; ND	10 versus 8	4 versus 6	Nil	Microvessel density mean (%CI): 60 (55–65) versus 71 (64–78); VEGF mean (%CI): 47 (43–52) versus 61 (54–67);

Donohue et al. 2002 [7]	32 versus 36	Mean (range): 69.9 (52–81) versus 70.2 (54–86); ND	Mean (range): 17.9 (3–61) versus 18.6 (3.5–54); ND	Mean (range): 5.4 (0.6–40) versus 6 (0.4–60); ND		4 versus 6	1 transfusion in the placebo group	Hb (gm/dL) decrease mean (range): preop-recovery = 1.56 (0.1–5.1) versus 1.86 (0.8–4.4); (ND) preop-day 1 = 0.99 (0.1–3.3) versus 1.48 (1.2–4.4); (ND) Hb loss (gm) mean (range): irrigation fluid = 43.6 (6–182) versus 69.3 (7–228); Gm. per/resected tissue = 2.64 (0.3–6.33) versus 4.65 (1.04–28);

Sandfeldt et al. 2001 [11]	26 versus 29	Median: 69 (56–78) versus 68 (54–76); ND	Median: 20 (12–30) versus 17.5 (10–31); ND	Median: 3 (2–5.2) versus 2.3 (2–5.8); ND		3	1 transfusion in the placebo group Readmission due to bleeding: 3 versus 2.	Blood loss: median = 279 (84–555) versus 287 (71–777) MVD = 24 (15–34) versus 22 (11–35); ND Blood loss/resection weight (mL/g) median: 14.5 (6.6–26.8) versus 16.4 (7.1–29.3); ND Blood loss/resection weight (mL/g) in prostates ≥18.6 g median: 547 versus 324;

(b)


Özdal et al. 2005 [10]	2003-2004	5 mg finasteride for 4 weeks prior to TURP or placebo Included PSA < 4

Donohue et al. 2005 [1]	No time	5 mg finasteride for 2 weeks prior to TURP or placebo	MVD: measured by counting stained blood vessels in 10 consecutive nonoverlapping high power fields (×200) beneath the prostatic urothelium on two slides	VEGF: (proportion of staining versus absent/faint staining)

Donohue et al. 2002 [7]	No time	5 mg finasteride for 2 weeks prior to TURP or placebo	Measured HB before and after TURP (recovery room) and the following day. Blood loss during surgery: measuring HB concentration in the irrigating fluid multiplied by the total volume of irrigating fluid used.

Sandfeldt et al. 2001 [11]	August 1998–May 1999 Seemed to include pateints with PSAs < 2	5 mg finasteride for 12 weeks prior to TURP or placebo	Blood loss was measured by Hb concentration in each collecting bucket which was measured in duplicate by a HemoCue Low HB System, consisting of a photometer and disposable microcuvettes. The mean of the two values was multiplied by the fluid volume to yield the Hb content in each bucket. The total blood loss was obtained as the sum of the Hb content in all buckets used divided by the preoperative blood Hb concentration.	MVD: counting the number of blood vessels below the suburothelial connective tissue with an average vessel density per unit grid obtained as the mean of 30 grids per patient.

Hagerty et al. 2000 [8]	May 1996–March 1998	5 mg finasteride for 8–16 weeks prior to TURP or placebo

NA: not available; ND: no difference between the groups.