PKC-Dependent Signaling Pathways within PAG and Thalamus Contribute to the Nitric Oxide-Induced Nociceptive Behavior

<table>Allodynia and hyperalgesia produced by NO donors’ administration underly a PKC-mediated pathway. The PKC blocker calphostin C (calph; 0.2 <i>μ</i>g per mouse i.c.v.) reversed cold allodynia (a) and heat hyperalgesia (b) induced by SNP. Calphostin C (c) completely prevented the SNP-induced upregulation of pPKC<i>γ</i> (c) and pPKC<i>ε</i> (d) within PAG and thalamus. <svg height="13.95" id="M5" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with SNP-treated group.</table>

International Scholarly Research Notices

fig2

Figure 2

Figure 2: PKC-Dependent Signaling Pathways within PAG and Thalamus Contribute to the Nitric Oxide-Induced Nociceptive Behavior 