Effect of Diazepam on Severity of Acute Pancreatitis: Possible Involvement of Peripheral Benzodiazepine Receptors
Figure 1
(a) Effect of diazepam on serum amylase level (U/L) of cerulein-induced acute pancreatitis in mice. Sham: normal mice treated with normal saline (5 mL/kg i.p. and 2 μL i.c.v), NegCtrl: mice with pancreatitis treated with normal saline (5 mL/kg i.p. and 2 μL i.c.v.), Diazepam: treated mice (5, 10, and 20 mg/kg i.p. and 10 μg i.c.v.), Diaz + flu: diazepam (20 mg/kg i.p.) + flumazenil (1 mg/kg i.p.). Data are shown as means ± SEM of 6 animals for each group. *, **, *** versus negative control (ANOVA). (b) Effect of diazepam on serum lipase level (U/L) of cerulein-induced acute pancreatitis in mice. Sham: normal mice treated with normal saline (5 mL/kg i.p. and 2 μL i.c.v), NegCtrl: negative control, mice with pancreatitis treated with normal saline (5 mL/kg i.p. and 2 μ i.c.v.), Diazepam: treated mice (5, 10, and 20 mg/kg i.p. and 10 μg i.c.v), Diaz + flu: diazepam (20 mg/kg i.p.) + flumazenil (1 mg/kg i.p.). Data are shown as means ± SEM of 6 animals for each group. **, *** versus negative control (ANOVA).
