Effect of Diazepam on Severity of Acute Pancreatitis: Possible Involvement of Peripheral Benzodiazepine Receptors
Figure 3
Effect of diazepam on pancreatic MPO (myeloperoxidase) activity (U/g wet tissue) of cerulein-induced acute pancreatitis in mice. Sham: normal mice treated with normal saline (5 mL/kg i.p. and 2 μL i.c.v.), NegCtrl: negative control, mice with pancreatitis treated with normal saline (5 mL/kg i.p. and 2 μL i.c.v.), Diazepam: treated mice (5, 10, 20 mg/kg i.p. and 10 μg i.c.v.), Diaz + flu: diazepam (20 mg/kg i.p.) + flumazenil (1 mg/kg i.p.). Data are shown as means ± SEM of 6 animals for each group. *, *** versus negative control (ANOVA).
