In Vivo and In Vitro Antidiabetic Activity of Terminalia paniculata Bark: An Evaluation of Possible Phytoconstituents and Mechanisms for Blood Glucose Control in Diabetes
Table 5
Glucose uptake in L6 rat muscle cells after 48 h incubation in media with glucose (2 g/L).
Treatment
Concentration
Glucose consumption (mg/100 mL)
Absence of insulin
Presence of insulin (1 mol/L)
Vehicle control
0.1% DMSO
2.95 ± 0.07
7.17 ± 0.03
Metformin
0.01 mM
7.80 ± 0.06a
8.96 ± 0.03a
0.1 mM
4.84 ± 0.09a
7.68 ± 0.13a
AETPB
0.5 g/mL
4.77 ± 0.07a
7.69 ± 0.06a
5 g/mL
4.05 ± 0.08a
7.79 ± 0.05a
10 g/mL
3.98 ± 0.07a
7.96 ± 0.04a
Gallic acid
0.05 M
4.04 ± 0.05a
7.96 ± 0.09a
0.5 M
3.96 ± 0.07a
7.87 ± 0.10a
5 M
3.58 ± 0.14a
7.83 ± 0.09a
The data represented as mean ± SD (). P < 0.001 metformin, AETPB, and gallic acid compared with vehicle control.
