Research Article
Delayed Asthmatic Response to Allergen Challenge and Cytokines Released by Nonspecifically Stimulated Blood Cells
Table 4
Single determination of cytokine concentrations in the (nonstimulated) serum (pg/mL).
| |
Patients
DYAR
| Control subjects | | BA patients | Healthy subjects | | IAR | LAR | DLAR | | | | |
| | IL-1β | 1.4 ± 0.2 | 1.9 ± 0.7 | 1.8 ± 0.6 | 1.7 ± 0.4 | 1.8 ± 0.2 | | IL-2 | 4.8 ± 1.6+ | <3.0 | <3.0 | 3.0 ± 0.3 | 3.1 ± 0.3 | | IL-3 | <31.2 | <31.2 | <31.2 | <31.2 | <31.2 | | IL-4 | 3.4 ± 0.9 | 5.9 ± 2.2+ | 4.6 ± 1.0 | 5.1 ± 0.4 + | 3.5 ± 0.3 | | IL-5 | 3.9 ± 1.0 | 7.1 ± 1.2
*
| 4.5 ± 0.6 | 4.9 ± 1.1 | 4.0 ± 0.7 | | IL-6 | <4.0+ | 5.8 ± 1.1 | 5.3 ± 0.4 | 6.7 ± 1.5
*
| 5.1 ± 0.4 | | IL-7 | 1.4 ± 0.3 | 1.9 ± 0.8 | 1.3 ± 0.5 | 1.7 ± 1.0 | 1.2 ± 0.3 | | IL-8 | 6.1 ± 1.2 | 6.0 ± 1.4 | 9.5 ± 2.1
*
| 8.3 ± 1.5+ | 5.3 ± 0.6 | | IL-10 | 3.7 ± 0.3 | 4.0 ± 0.6 | 6.2 ± 0.5 | 7.1 ± 0.6+ | 4.1 ± 1.0 | | IL-12p40 | 7.6 ± 2.1 | 6.9 ± 1.8 | 8.1 ± 4.2 | 9.8 ± 2.1+ | 7.9 ± 1.4 | | IL-12p70 | 8.9 ± 1.1 | 9.6 ± 1.3 | 9.4 ± 0.5 | 9.3 ± 1.0 | 9.2 ± 2.0 | | IL-13 | <3.0 | 4.7 ± 0.5+ | 3.3 ± 0.2 | 3.9 ± 0.4 | <3.0 | | IL-18 | 10.5 ± 0.4 | 13.8 ± 0.9+ | 17.0 ± 2.3
*
| 14.8 ± 1.5
*
| 10.0 ± 2.1 | | IFN- | 2.9 ± 0.3+ | <1.0 | <1.0 | <1.0 | <1.0 | | GM-CSF | <3.0+ | 5.1 ± 1.6 | 5.3 ± 0.8 | 4.6 ± 0.7 | 3.8 ± 0.5 | | G-CSF | <0.8 | <0.8 | <0.8 | <0.8 | <0.8 | | TNF- | 6.8 ± 0.5 | 7.2 ± 1.1 | 8.3 ± 0.7+ | 5.5 ± 1.0 | 6.4 ± 0.5 | | TGF- | 12.3 ± 4.0 | 12.9 ± 2.1 | 17.1 ± 5.0+ | 14.0 ± 2.3 | 12.5 ± 4.0 |
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Values = mean ± SEM; Statistical significance as compared with healthy subject values: *; + (borderline).
DYAR: delayed asthmatic response; IAR: immediate asthmatic response; LAR: late asthmatic response; DLAR: dual late asthmatic response.
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