Clinical Study
Cognitive Dysfunction and Dementia in Primary Sjögren’s Syndrome
Table 2
Results of cognitive tests in patients with primary Sjögren’s syndrome, multiple sclerosis, and controls.
| |
Cognitive tests | Mean score (SD) | P value
| | Patient with PSS () | Patient with MS () | Controls () | PSS versus controls | MS versus controls | PSS versus MS |
| | Selective reminding test (SRT) | | | | | | | | Mean number of words | 9.9 (2.4) | 9.4 (2.2) | 11.6 (1.4) | .001 | <.0001 | NS | | Learning | 56.7 (24.5) | 49.9 (24.1) | 69.7 (16.4) | .047 | .002 | NS | | SRT-DR (delayed recall) | 12.0 (3.2) | 11.6 (2.8) | 13.7 (1.5) | .045 | .003 | NS | | 10/36 Spatial recall test | | | | | | | | Immediate recall | 14.5 (6.2) | 13.8 (4.7) | 17.8 (4.7) | .049 | .007 | NS | | Delayed recall | 4.7 (2.3) | 5.3 (2.2) | 6.8 (2.4) | .001 | .031 | NS | | Digit Span | | | | | | | | Forward | 5.6 (1.9) | 6.3 (2.0) | 7.5 (1.3) | <.0001 | 0.042 | NS | | Backward | 5.2 (1.7) | 5.8 (1.9) | 6.4 (2.1) | .03 | NS | NS | | Digit symbol substitution test (DSST) | 44.8 (11.3) | 43.1 (13.2) | 61.5 (15) | <.0001 | <.0001 | NS | | Paced auditory serial addition test (PASAT) | | | | | | | | 3 s | 34.7 (15.8) | 32.7 (15.8) | 46.7 (8.5) | .005 | <.0001 | NS | | 2 s | 22.4 (13.6) | 22.8 (13.8) | 35.8 (9.6) | .001 | .001 | NS | | Crossed tapping | 3.9 (8.0) | 3.1 (7.0) | 0.4 (0.8) | .008 | .031 | NS | | Go-No-Go | 1.8 (3.0) | 0.9 (1.1) | 0.4 (0.6) | .047 | NS | NS | | Fluencies | | | | | | | | Phonemic | 13.7 (5.0) | 12.6 (5.5) | 16.9 (5.4) | .036 | .005 | NS | | Semantic | 19.3 (4.7) | 17.8 (5.4) | 23.1 (4.4) | .011 | <.0001 | NS | | Nb subjects with 4 subtests <5e centile (%) | 15 (60) | 19 (76) | 0 (0) | <.0001 | <.0001 | NS |
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PSS: primary Sjögren’s syndrome; MS: multiple sclerosis; Nb: number; NS: nonsignificant; SD: standard deviation.
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