Development and Validation of a Stability Indicating RP-HPLC Method for the Determination of Two Sun Protection Factors (Koptrizon and Tinosorb S) in Topical Pharmaceutical Formulations Using Experimental Designs
Table 6
ANOVA for 23 full factorial design: response: RT of Koptrizon (min).
Source
Sum of squares
df
Mean square
value
value prob >
Model
0.073284126
3
0.024428
743.3259616
<0.0001
Significant
A—flow
0.008862903
1
0.008863
269.6911034
<0.0001
B—column temp.
0.009766119
1
0.009766
297.1752743
<0.0001
C—THF comp.
0.054655104
1
0.054655
1663.111507
<0.0001
Curvature
1
2.68560136
0.1622
Not significant
Residual
5
Lack of fit
0.000164316
4
Pure error
0
1
0
Cor total
0.073536699
9
Std. dev.
0.006488107
0.996565345
Mean
0.591672677
Adjusted
0.994848018
Values of prob > less than 0.05 indicates that model is significant.