Development and Validation of a Stability Indicating RP-HPLC Method for the Determination of Two Sun Protection Factors (Koptrizon and Tinosorb S) in Topical Pharmaceutical Formulations Using Experimental Designs
Table 7
ANOVA for 23 full factorial design: response: RT of Tinosorb S (min).
Source
Sum of squares
df
Mean square
value
value Prob >
Model
0.057184881
3
0.019061627
630.2536737
<0.0001
Significant
A—flow
0.006317517
1
0.006317517
208.8823992
<0.0001
B—column temp.
0.007126362
1
0.007126362
235.6260641
<0.0001
C—THF comp.
1
0.043741001
1446.252558
<0.0001
Curvature
1
0.055223918
0.8235
Not significant
Residual
5
Lack of fit
4
2.071326494
0.4746
Not significant
Pure error
1
Cor total
0.057337773
9
Std. dev.
0.005047971
0.997333484
Mean
0.484279065
Adjusted
0.996000226
Values of prob > less than 0.05 indicates that model is significant.