Review Article

Role of Obesity in Asthma Control, the Obesity-Asthma Phenotype

Table 2

Studies of obesity as a risk factor for asthma control and severity.

Study Study populationNumber of subjectsResults

Barros et al., 2011 [22]Patients with severe asthma in Brazil508Obese asthmatics had worse asthma control
Peters et al., 2011 [27]Adult outpatients in South Texas429Obese asthmatics had worse quality of life and lower FVC but no difference in asthma severity and health care utilization
Youkou et al., 2011 [30]Japanese outpatients3146Obese asthmatics had more severe disease and higher utilization of inhaled salmeterol and leukotriene receptor antagonists
Sastre et al., 2010 [32]Spanish outpatients607No significant association between obesity and asthma control
Stanford et al., 2010 [18]American outpatients2238Obesity was associated with worsened asthma control as measured by ACT.
Clerisme-Beaty et al.,
2009 [33]
Urban outpatients in the United States292No association between asthma control and obesity
Demoly et al., 2009 [20]European internet survey2337Obesity was associated with worsened asthma control as measured by ACT.
Haselkorn et al., 2009 [31]Adult outpatients2396Worsened control of asthma with weight gain
Lessard et al., 2008 [24]Adult outpatients in Canada88Obese asthmatics had worse asthma control
Mosen et al., 2008 [25]Adult members of managed care organization1113Obese asthmatics had worse asthma-related quality of life, asthma control, and history of asthma related hospitalizations.
Taylor et al., 2008 [29]Outpatient adults from 4 states3095Obese asthmatics had worse more severe asthma based on measurement of several different factors
Schatz et al., 2007 [19]Adult members of managed care organization570Obesity was associated with worsened asthma control as measured by ACT.
Laforest et al., 2006 [21]French outpatients 1282Obesity was associated with worsened asthma control as measured by ACT.
Lavoie et al., 2006 [23]Canadian outpatients382Obese asthmatics had worse asthma control and quality of life but not asthma severity
Saint-Pierre et al., 2006 [26]French outpatients, from 4 university-based clinics406Overweight/obese asthmatics less likely to develop better control of asthma
Akerman et al., 2004 [28]Adults outpatients in the United States143Linear relationship between asthma severity and BMI