Research Article
Development and Evaluation of Insulin Incorporated Nanoparticles for Oral Administration
Table 4
Mean blood glucose change (% base level) ± SD of diabetic rats after different treatments.
| | Treatment | Blood glucose change (% base level) of diabetic rats at different time intervals
(Mean ± SD) | | 0 hr | 1 hr | 2 hrs | 3 hrs | 4 hrs | 5 hrs | 6 hrs | 10 hrs | 14 hrs | 18 hrs |
| | Gr 1 | 100 ± 00 | 105.51 ± 3.47 | 104.05 ± 1.77 | 106.27 ± 4.45 | 105.74 ± 4.38 | 102.51 ± 5.43 | 107.21 ± 1.97 | 104.28 ± 3.70 | 107.21 ± 2.88 | 105.59 ± 6.59 |
| | Gr 2 | 100 ± 00 | 103.13 ± 7.17 | 102.75 ± 4.58 | 102.89 ± 4.17 | 103.17 ± 3.59 | 101.66 ± 5.14 | 104.48 ± 4.59 | 101.93 ± 6.66 | 100.25 ± 7.84 | 102.75 ± 3.67 |
| | Gr 3 | 100 ± 00 | 98.55* ± 1.28 | 95.08*** ± 2.41 | 93.86*** ± 2.40 | 93.51*** ± 3.42 | 95.50 ± 2.44 | 97.73* ± 1.66 | 98.09 ± 1.67 | 99.33 ± 2.97 | 101.12 ± 3.10 |
| | Gr 4 | 100 ± 00 | 74.90*** ± 4.14 | 64.26*** ± 3.70 | 60.15*** ± 3.10 | 57.74*** ± 2.81 | 53.46*** ± 2.19 | 56.50*** ± 2.28 | 73.20*** ± 5.91 | 90.52*** ± 5.02 | 101.79 ± 1.49 |
| | Gr 5 | 100 ± 00 | 26.43*** ± 1.30 | 18.83*** ± 0.64 | 38.02*** ± 3.66 | 52.00*** ± 3.94 | 65.95*** ± 4.03 | 74.91*** ± 1.49 | 86.72*** ± 3.10 | 97.01** ± 2.91 | 102.13 ± 2.22 |
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