Hemin and Zinc Protoporphyrin IX Affect Granisetron Constipating Effects In Vitro and In Vivo
Figure 3
Effect of in vivo administration of ZnPPIX, hemin, or granisetron alone and in combination on the time to first defecation in rats. (a) ZnPPIX and hemin do not affect the time to first defecation. (b) Granisetron significantly increases this parameter at higher doses used. (c) Preadministration of ZnPPIX reduces the time to first defecation in rats treated with granisetron to control levels. (d) Hemin administered before granisetron significantly increases the time to first defecation compared to basal levels. Values are expressed as mean ± SEM of 8–12 experiments. and versus their respective control.
