Hemin and Zinc Protoporphyrin IX Affect Granisetron Constipating Effects In Vitro and In Vivo

<table>Expression of HO-1 and HO-2 in duodenum from rats treated with hemin. Representative anti-HO-1 (a), anti-HO-2 (b) immunoblots of duodenal homogenates from vehicle- and hemin-treated rats (upper panels), and quantitative densitometry (lower panels). Increased expression of HO-1 was found in hemin- (50 <i>μ</i>M/kg)-treated rats compared to control. No difference in HO-2 expression was found among groups. Values are expressed as mean ± SEM of 3 experiments. <svg height="13.95" id="M154" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus WKY (Newman-Keuls multiple comparison test). </table>

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fig5

Figure 5

Figure 5: Hemin and Zinc Protoporphyrin IX Affect Granisetron Constipating Effects In Vitro and In Vivo 