Research Article
Hemin and Zinc Protoporphyrin IX Affect Granisetron Constipating Effects In Vitro and In Vivo
Table 2
Effect of in vitro administration of ZnPPIX alone or in combination with granisetron (G) on the components of EFS response of duodenal preparations.
| Treatments (m) | Area under the curve (% SNP) | | Minimum value (% mean basal tone) | | Off contraction (% mean basal tone) | | 3 Hz | 5 Hz | 10 Hz | 3 Hz | 5 Hz | 10 Hz | 3 Hz | 5 Hz | 10 Hz |
| Basal | | | | | | | | | | | | | ZnPPIX 10 | | | | 0.05 | | | | n.s. | | | | n.s. | ZnPPIX + G 0.1 | | | | n.s. | | | | n.s. | | | | 0.05 | ZnPPIX + G 0.3 | | | | n.s. | | | | n.s. | | | | 0.05 | ZnPPIX + G 1 | | | | 0.05 | | | | n.s. | | | | 0.05 |
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